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Mark Billadeau

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About Mark Billadeau

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  • Gender
    Male
  • Location
    Middletown, MD
  • Interests
    science, working dogs, sheep

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  1. Mark Billadeau

    HSF4 gene mutation in Border Collies

    Using the following search string I used google scholar to locate any publications on Border Collies and the mutation HSF4: +HSF4 +Mutation +"Border Collie" This string requires all three terms (HSF mutation "border Collie") be present in the text. The search returned 16 hits. These hits were for articles that discussed genetic mutations in various breeds where HSF4 was discussed as being present in other breeds and Border Collie had different mutations discussed. I did not find any published articles where Border Collies were identified as having HSF4. One article did summarize the findings of several studies on HSF4 in various breeds; the summary included a list of breeds that were tested and found to not have HSF4. Border Collie was not among the breeds listed as having been tested. https://cgejournal.biomedcentral.com/articles/10.1186/2052-6687-1-3 In the article above (The Genetics of Eye Disorders in the Dog), Border Collies are only discussed as having Primary lens luxation and Late-onset forms of PRA.
  2. Mark Billadeau

    HSF4 gene mutation in Border Collies

    I’ll check google scholar tomorrow
  3. Mark Billadeau

    HSF4 gene mutation in Border Collies

    Go read the original research not opinions posted in forums or companies offering genetic tests. I searched for +hsf4 +”border collie” on google and found nothing.
  4. Clearly the airline carrier did not require a recent health cert prior to flying.
  5. Mark Billadeau

    MDR1 - can we eradicate?

    You want the HEF website update to be accurate (recessive is not accurate and it has been corrected) but then you want us to post inaccurate information (dominant is not accurate based upon WSU published peer reviewed research). You want the HEF website to educate using up to date information and genetic language (not just lay descriptions) but then you dont want us to use correct genetic language. I too find this pointless.
  6. Mark Billadeau

    MDR1 - can we eradicate?

    According to the WSU published research Homozygous mutants have no p glycoprotein production while heterozygots have some p glycoprotein production. Does that sound like the mutation fits the definition of dominant? A dominant gene would yield exactly the same phenotype with 1 or 2 copies of that gene.
  7. Mark Billadeau

    MDR1 - can we eradicate?

    WSU does not call it incomplete dominant like the other websites.
  8. Mark Billadeau

    MDR1 - can we eradicate?

    read the section on mdr1 posted here: https://bordercolliefoundation.org/health-and-eduction/genetic-diseases/
  9. Mark Billadeau

    MDR1 - can we eradicate?

    were the authors of these websites geneticists? Many of the websites I saw using these terms were marketing tests. What language does WSU use?
  10. Mark Billadeau

    MDR1 - can we eradicate?

    Read this http://www.instituteofcaninebiology.org/blog/the-science-of-dog-breeding-in-the-era-of-genomic-selection
  11. Mark Billadeau

    MDR1 - can we eradicate?

    Unless we are looking at diversity as part of our breeding strategy, two breeders that dont breed alike can both be decreasing diversity. Breeding for the same type decreases diversity. Diversity of a closed gene pool cannot increase; all we can do is slow the decrease in diversity.
  12. Mark Billadeau

    MDR1 - can we eradicate?

    dont think in terms of within one year but in terms of how many times a dam or sire is contributing to the gene pool Do you think they are breeding and individual dog once or twice and then replacing that breeding dog with different genetics or rebreeding multiple times? Go read the intro to the hvb list to get a better understanding of the purpose. It is to promote testing of phenotypes as part of the breeding decision process.
  13. Mark Billadeau

    MDR1 - can we eradicate?

    What amount of genetic diversity do you think HVBs are contributing to the gene pool; large numbers of genetically diverse pups or large numbers of genetically similar pups?
  14. Mark Billadeau

    MDR1 - can we eradicate?

    Read this http://www.instituteofcaninebiology.org/blog/why-you-should-care-about-effective-population-size And this http://www.instituteofcaninebiology.org/blog/how-to-win-the-health-test-game_
  15. Mark Billadeau

    MDR1 - can we eradicate?

    Watch this educational video which discusses to not use co-dominance or incomplete dominance http://www.instituteofcaninebiology.org/blog/its-not-always-as-simple-as-dominant-and-recessive
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