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Mark Billadeau

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About Mark Billadeau

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    Bill Nye Wannabe

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    Middletown, MD
  • Interests
    science, working dogs, sheep

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  1. As far as I am aware no marker has been identified for cHD. I believe the general consensus is cHD is polygenic plus environmental factors.
  2. All of the researchers the ABCA has worked with (over the time frame I’ve been involved) have shared confidential information with the committees.
  3. You asked questions on test methodology, hearing controls, etc.; these are addressed in the methods and materials section of publications. how to use the test results is what you need to know; as Eileen stated we’re working on it. They have shared confidential details with which we will develop our recommendations. Do you really need to know all the other details you’re asking about?
  4. Some of your questions may be answered in the published EAOD study which included the univ of Finland group: Variation in Genes Related to Cochlear Biology is Strongly Associated with Adult-Onset Deafness in Border Collies, 2012, https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1002898
  5. I suggest you post this question in the general discussion forum as opposed to this “Forum for those engaged in training their border collies for livestock operations and ISDS-style trials.” Your question will get more visibility and responses there.
  6. We let the researchers complete their ongoing studies which are funded by the hef
  7. frequency rates are determined by the genetic results in the dogs tested 35% of the dogs tested were heterozygous for the risk variants
  8. The methods used to amplify specific DNA sequences is under patents and licensed to many manufacturers of dna tests the dna chips used to detect specific DNA sequences are manufactured by 2 or 3 companies and sold for used to other companies All a company will need is the DNA sequences and they will be able to develop a test using their preferred dna chip or dna testing technology question for you, were these rumors started by people who work at genoscoper or at least in the dna testing field or by those who like to postulate conspiracies?
  9. The US Supreme Court ruled genetic tests cannot be patented; which is why other companies besides Optigen now provide a test for CEA. This has been addressed by Eileen several times
  10. “It also seems that the influence of genes on the choice to own a dog is stronger in women than in men.” While the scientific publication likely does not claim genes cause dog ownership; the popular press summary of the study has statements implying the genes do control it.
  11. Having been involved with multiple launches of new commercial diagnostic tests, I am not surprised the time lines have slipped. It is not uncommon for the final details in the development process to not go as one anticipated. It is better for us that they make sure every thing about this test (all the reagents used for every individual test run and the details of how each test is to be run) is accurate and reproducible. Getting a new test ready for the market can be like getting a new dog ready for trialing. You can set a particular trial as your goal but if your dog is not ready is it better to disappoint friends who want to see your new dog or to run your unprepared dog?
  12. We too feed raw eggs; those eggs which our chickens have made too dirty for us to want to consume. As an aside the avidin biotin interaction may be the most biomedically important interaction in that it is used in a significant percentage of biomarker blood tests used in medicine and medical research.
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