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Mark Billadeau

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About Mark Billadeau

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    Bill Nye Wannabe

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  • Gender
    Male
  • Location
    Middletown, MD
  • Interests
    science, working dogs, sheep

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  1. Mark Billadeau

    Donald McCaig

    I will miss my friend.
  2. Mark Billadeau

    MDR1 - can we eradicate?

    For hw the mutation is irrelevant
  3. Mark Billadeau

    MDR1 - can we eradicate?

    History is not wrong, it is simply a record of what was known at that time. Clearly you understand this since you pointed out the updates that were also posted. Instead of nitpicking historical posts you should have proposed pinning a link to the HEF health page at the top of this section.
  4. Mark Billadeau

    MDR1 - can we eradicate?

    You don’t think readers will comprehend that quote with the associated date (2007) may not reflect what is known in 2018 or some future date? You would prefer we change the historical records?
  5. Mark Billadeau

    MDR1 - can we eradicate?

    Go review the information posted; there are several posts indicating the presence of the allele (look up the definition if you don’t know) at low frequencies in border collies from several studies. The discussion was on how the dogs were assigned to a breed in those studies. [Test methods used in studies can impact how to interpret the results. This continues to be important when looking at the results of genetic studies which is why it is important to read the original publication as opposed to a summary prepared by the general press. In the case of genetic association studies it is very important to scrutinize how the individuals were assigned a phenotype to which the genetic data will be correlated.] Historically people (including Vets) thought border collies were just as impacted by this disease as collies which is why the information provided was controversial for the general public. The information on the safety of heartworm preventatives (at the prescribed dose) continues to be accurate and in agreement with the information on the WSU website.
  6. Mark Billadeau

    MDR1 - can we eradicate?

    Since two of you are “hung up” by my statement quoted above....... ”The Socratic method is a method of hypothesis elimination, in that better hypotheses are found by steadily identifying and eliminating those that lead to contradictions. The Socratic method searches for general, commonly held truths that shape beliefs and scrutinizes them to determine their consistency with other beliefs. The basic form is a series of questions formulated as tests of logic and fact intended to help a person or group discover their beliefs about some topic, exploring definitions and seeking to characterize general characteristics shared by various particular instances.” Question: would you ban an international champion if it were mdr1 m/n? The answers to this question provide information on what level of breeding restrictions the community wants put in place. Is the community that is promoting and preserving the working ability of the breed willing to exclude proven exceptional working dogs because of this genetic mutation. I have frequently used this method in threads on this forum.
  7. Mark Billadeau

    MDR1 - can we eradicate?

    My attitude/ire is brought out by the suggestion of a eugenics program with a limited view of the problem. We’re not dealing with just one genetic disease; there are several we know about and many more that will be identified in the future. This study surveyed 152 known diseases in dogs; many that are not tested for in our breed because we don’t recognize a high enough rate of the disease phenotype. But that does not mean there are no heterozygotes (i.e. carriers) in our breed. https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007361 We must stop looking at this one disease at a time (one dog at a time) or each disease as a separate problem. What we need is to focus on the entire gene pool/genome. We need to be breeding for genetic diversity not breeding to exclude every genetic disease for which there is a test. This is not a new idea; it’s not even the first time or the first thread where I’ve presented it. It’s not my idea. It has been promoted many times by others. Here is one of those times from 2016. https://www.instituteofcaninebiology.org/blog/three-key-strategies-to-reduce-genetic-disorders-in-dogs
  8. Ask your vet about them using an anti anxiety drug for a nail trim (like diazepam). Work with them to find a drug that is effective (lowers stress) when used under their supervision which can be prescribed later for you to use at home.
  9. Mark Billadeau

    MDR1 - can we eradicate?

    Assuming Hardy-Weinberg equilibrium for all genetic diseases with tests in our breed (CEA, TNS, IGS, NCL, MDR1) and published breed frequencies are accurate we desire to eradicate all these diseases by not breeding m/n or m/m dogs (“carrier” and “affected”) no dog has more than 1 of these diseases we would be excluding 49% of the population
  10. Mark Billadeau

    Concerns about MDR1

    Go read this https://learn.genetics.utah.edu/content/basics/patterns/
  11. Mark Billadeau

    Concerns about MDR1

    Go read the published articles in peer reviewed scientific literature (not lay person summaries) and there you’ll find they don’t talk dominant. Do you want scientifically accurate information and try to gain a better understanding of it or do you want it “dumb it down”
  12. Mark Billadeau

    Concerns about MDR1

    What will happen if our community decides to only breed dogs clear of every genetic disease where there is a test? 1. We breed out each genetic disease as each new test becomes available 2. We increase the co-efficient of inbreeding of our breed (can’t breed “affected” and “carriers” of cea, TNS, igs, mdr1, EAOD, test6, test7, test8,....) 3. We increase the risk of exposing a new genetic disease for which we can develop a genetic test (test9, test10, test11, .....) So do we set ourselves on the path towards what the collie is (higher level of inbreeding) by breeding out ever known genetic disease, choose to breed out selected genetic diseases (what criteria will be used to choose which diseases), or do we approach the increasing problem of more and more identified genetic diseases another way (breed for genetic diversity)?
  13. Mark Billadeau

    Concerns about MDR1

    If the mutation is dominant shouldn’t there be no differences in how the disease is manifested in mutant/mutant and mutant/normal dogs? But the research has clearly demonstrated that disease expression in mutant/normal dogs is less and less defined (a range) than in mutant/mutant dogs. Does that really fit the simple definition of a dominant trait? Most people want to get a simple answer on genetics: is my dog affected or not; they don’t want to deal with the actual complex genetic consequences. As such many writers will give what people want to hear: the simple binary answer.
  14. Mark Billadeau

    Concerns about MDR1

    The pharmacodynamics of Pyrantel Pamoate does not involve the p-glycoprotein pathways like ivermectin.
  15. Mark Billadeau

    Concerns about MDR1

    Have you obtained the genetic test or are you relying upon relationship information to presume genetic status? Sample quality can impact the results of genetic testing; no lab test is 100% accurate.
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