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Eileen Stein

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Posts posted by Eileen Stein

  1. What on earth makes you think “the HEF still thinks MDD/OS are one and the same with University of Helsinki”?  What does that even mean?  The HEF does not now think, and never has thought, that MDD/OS are one and the same with the University of Helsinki.

    I think we’ve taken this topic about as far as we can.  I’ve done my best to explain to you why the HEF is not able to make a recommendation about the test in the absence of hard data.  I understand that you disagree.  So there we are.

     

  2. 5 hours ago, Journey said:

    Whatever number I say it won't be good enough.

    No, it won’t, and you know why.  You know as well as I do that the handful of dogs whose results you’re aware of wouldn’t come within a mile of statistical significance.  Yes, MDD/OS does have numbers, if by numbers you mean they know how many dogs they’ve tested, and how many of them have 0, 1 or 2 copies of the markers they’re using.  But they don’t have numbers correlating those test results to to those dogs’ hearing/deafness history in any meaningful way.  If you don’t believe me, ask them next time you’re  in touch with them.  Don’t you think if they had data supporting the validity of their test they would be only too happy to publicize it?  

    And without that data, HEF is in no position to vouch for the accuracy of their test.  We all fervently wish we had a basis on which HEF could update its earlier statement regarding the test.  But wishing does not make it so.

  3. On 5/10/2023 at 11:38 PM, Journey said:

    What's been seen are the results people are seeing based on testing or not. The at risk dogs do have hearing loss. Agree, the carriers are a bit murkier but the test so far is pretty well nailing the deaf ones. Concrete data, none. First hand info from owners, lots. . . .  I can’t give you the data you are asking for.  Optical Selection though probably can.

    How many are “lots”?

    What makes you think Optimal Selection has this data?  Have they told you they have it?

  4. 22 minutes ago, Journey said:

    . . . .  Regardless of a position or lack thereof,  any options you see to get the testing a broader acceptance based on what's been seen for the past 4 years?

    What HAS  been seen for the past 4 years?  I asked you what concrete information/data you have and you haven’t replied.

  5. 4 hours ago, Journey said:

    Reaching out to MDD/OS would be a start. As much we all hate the monopoly factor they've been good to me in all the dealings I've had with them. I'm sure they have many of the answers you're seeking. That's just it, go look, ask, movement of some sort may produce productive insights. Sitting still has gotten us no where for how many years? To have litters born recently,  whole litters, at risk, is uncalled for. Yes, it's happening. 

    What makes you think HEF has been “sitting still” and not “reaching out”?  What makes you “sure they have many of the answers [we’re] seeking”?

  6. 2 hours ago, Journey said:

    Not to face disappointment again but still no word on anything from Dr Lohi? . . . .

    While it may not be to the liking of the HEF, can we put aside the issue of Dr Lohi breaking contracts, not giving data/info he was supposed to, and move on to actually helping the dogs and breeders? People may not like it but the test is proving to be uncannily accurate with "at risk" dogs. Surely the HEF can say this, no? 

     

    Well no, Karen, we can't say this because we don't know it to be true.  We have no data which would support a statement that the test is proving to be uncannily accurate with "at risk" dogs.  If you have such data, I can understand why you would want to make it known.  How many of the 426 (source?) dogs with 2 copies do you actually know to be deaf prior to 8-9 years of age?  What knowledge do you have of the hearing status of the rest of those 426 dogs?

    It would be very much to the liking of the HEF to actually help the dogs and breeders.  That is our purpose for existing.  We just do not currently have a basis for making claims about the accuracy of the test, and no one regrets that more than I do. 

  7. White tail tips are not uncommon in dogs, and there's a good reason for it.  As I understand it, melanin moves outward from the spinal column during the dog's development, mostly pre-natal but also post-natal.  (That's why the black on a dog may increase after birth, but the white never does.)  So the regions more remote from the spinal column are more likely to be white (paws, tail tip, even the chest and abdomen), because the melanin "flow" stops before it reaches that far. 

    Also, the term "gay tail" doesn't refer to white on the tail tip, but to a tail that is held high, rather than parallel to or lower than the spinal column.  Old time shepherds (and even some modern ones) don't like to see a gay tail on a border collie, because a seriously working border collie will be carrying its tail low.

  8. There's an article called "Understanding the Multi-Drug Resistant Gene Mutation in Border Collies" on the ABCA Health & Education Foundation's website that y'all may find to be helpful:

    https://bordercolliefoundation.org/wp-content/uploads/2020/08/Understanding_MDR1_Jul-2020.pdf

    This is the meat of the explanation:

    Quote

    The MDR1 gene (also sometimes referred to as the ABCB1 gene) produces a protein that protects the brain from certain drugs and also aids in clearing these drugs from the body through organs such as the liver and kidneys. . . .  The MDR1-1Delta mutation interferes with this important protective function. Like most single gene mutations, a dog can have one mutated MDR1 gene and one normal gene (heterozygote) or two mutated genes (homozygote). One copy of the gene is contributed by each parent. A dog that carries two copies of the mutation will not produce any of the protective protein, and it will pass one copy of the mutated gene to all of its offspring. A dog that carries one copy of the mutation will pass on a copy of the mutation to roughly half of its offspring. But in one very important respect, the dog that carries a single copy of the mutated MDR1 gene is different from the "carrier" dogs who are heterozygous for other most commonly known mutations, such as CEA, where a heterozygote is an unaffected carrier:  The dog who is heterozygous for the MDR1-1Delta mutation may display symptoms of the disorder. Because each of the two genes separately produces the MDR1 protein, his normal gene will produce the protective protein, but the mutant gene will not. Depending on other regulating factors present in the body at the time, a “carrier” of the MDR1 gene mutation has the potential to produce only half or less of the normal MDR1 protein needed to protect its brain from certain drugs. As a result, these heterozygous dogs range from essentially normal to mildly affected to significantly affected, with the most being mildly affected.

    I'm not sure that any variant of the "dominant/recessive" terminology is meaningful in this case.  Due to the function that the gene performs, I would say that the wild (normal) allele is doing its thing, which is to produce the protein, and the mutated allele is doing its thing, which is not to produce the protein.  It's not a case of the normal allele masking or suppressing the effect of the mutated allele.   

  9. Is there something that causes her to try to break out?  A thunderstorm, or a high-pitched noise, or something like that?  Will she do it when you're home, or only when there's nobody at home with her?

    I understand your not wanting to think of her being locked up in a crate, but that is really the best answer.  Pathetic as a dog in a crate may look, most of them really like their crates once they get used to them.  if you can trust her when you're at home, you can have her out then for quality time.  If she's reluctant to go in her crate at first, you might start feeding her meals in there.  I don't think an electric fence would contribute anything at all -- I think crating her is the answer.

    BTW, I am moving this thread down to General Border Collie Discussion, because this forum is for training border collies to work livestock.

  10. Sharing a message from Bob Stephens, President of the Canadian Border Collie Association:

    Fellow sheep dog enthusiasts;

    The Canadian Border Collie Association is pleased to announce the release of the documentary film Amanda Milliken In Conversation. The film is an intimate portrait which offers a rare glimpse into Amanda’s thinking on breeding, training and handling sheep dogs.

    Amanda tells us how she got started in her career and we join her on the field as she trains her current young dog and talks about her approach to building the partnership that has made her a winner over and over again.

    She recounts the story of the ‘dog wars’ - the dramatic fight to preserve the working Border collie, a fight that resulted in the establishment of  Canada’s breed registry; the Canadian Border Collie Association. 

    She shares memories and anecdotes, sometimes humorous, from the early years of herding in Ontario;  how trial competition refined the skills of both dogs and handlers and how the Kingston Sheep Dog Trials grew from a humble event in her back field to one of the most important herding trials in North America. 

    Amanda Milliken In Conversation  is an entertaining and educational portrait of one of our sports’ most accomplished members. It is full of gems for sheep doggers of all levels.

    We invite you to share this film with your members on your website and social media pages.  It can be found here:  https://www.canadianbordercollies.org/showcase-amanda

    Sincerely,

    Bob Stephens

    President, Canadian Border Collie Association

  11. Sharing a message from Bob Stephens, President of the Canadian Border Collie Association:

    Fellow sheep dog enthusiasts;

    The Canadian Border Collie Association is pleased to announce the release of the documentary film Amanda Milliken In Conversation. The film is an intimate portrait which offers a rare glimpse into Amanda’s thinking on breeding, training and handling sheep dogs.

    Amanda tells us how she got started in her career and we join her on the field as she trains her current young dog and talks about her approach to building the partnership that has made her a winner over and over again.

    She recounts the story of the ‘dog wars’ - the dramatic fight to preserve the working Border collie, a fight that resulted in the establishment of  Canada’s breed registry; the Canadian Border Collie Association. 

    She shares memories and anecdotes, sometimes humorous, from the early years of herding in Ontario;  how trial competition refined the skills of both dogs and handlers and how the Kingston Sheep Dog Trials grew from a humble event in her back field to one of the most important herding trials in North America. 

    Amanda Milliken In Conversation  is an entertaining and educational portrait of one of our sports’ most accomplished members. It is full of gems for sheep doggers of all levels.

    We invite you to share this film with your members on your website and social media pages.  It can be found here:  https://www.canadianbordercollies.org/showcase-amanda

    Sincerely,

    Bob Stephens

    President, Canadian Border Collie Association

  12. I contacted Dr. Pearce-Kelling about this project when I first heard about it.  She said she would get in touch with Greg Acland (whom she knows from her OptiGen days) to discuss this with him and ascertain his current opinion on the existence or prevalence of PRA in border collies.  He is retired now but I'm sure he keeps up with this subject, and I myself know of no published research later than a French study in 2008, which Greg was aware of at the time and which did not change his opinion.

    Dr. PK's study could be a useful one, but I would expect there would be difficulty in finding border collies with genuine, proven PRA to serve as subjects.

  13. I'm on the east coast, but we had a high level haze that is hiding the sun for most of the day, and the weather reporter said it was caused by smoke from out west being carried here by the jet stream.  Said it was at too high a level to be a breathing problem.  But talk about traveling a long distance!

    Sure glad to hear your nephew tested negative, Mark.

  14. The reason you haven't gotten any replies is that "ASK AN EXPERT is a forum for questions about training dogs to herd livestock ONLY.  So I'm going to move your posts to the GENERAL BORDER COLLIE DISCUSSION forum.

    In the meantime, I assume your dog has chewed your couch when you were not present, or gone to the bathroom in the basement when you were not present. If so, the most likely explanation is that your dog does not yet know that he is not supposed to do these things EVER, even when you are not there.  Dogs often associate learning with particular places -- just because he knows not to go to the bathroom in the living room doesn't mean he knows not to do it in the basement.  What measures have you used to try to make him understand this fully?

    At this stage I would not give him access to the whole basement when you are not there -- just to a smaller enclosed area where he is less likely to think it's okay to go.  And I would not give him access to the couch when you are not there to correct him if he starts to chew it.  Does he chew other things you don't want him to chew?

    It's easy for people to assume a dog understands something if they think it's obvious -- like you should not go to the bathroom in the house.  But really, why would a dog know this without thorough training to get the point across fully?

  15. The reason you haven't gotten any replies is that "ASK AN EXPERT is a forum for questions about training dogs to herd livestock ONLY.  So I'm going to move your posts to the GENERAL BORDER COLLIE DISCUSSION forum.

    In the meantime, I want to give you some reassurance.  Puppies will usually follow a moving person, until they get distracted by something else interesting, and an insecure pup will be hesitant to leave its person's side (not really a good thing).  But the kind of "attachment" you're talking about rarely comes in the first year or two of puppyhood.  It comes (in varying degrees, depending on the pup's individual personality) with maturity, as a bond gradually forms between the two of you from the time you spend together and the things you do together.  As the years go by, the attachment that forms between a good border collie and an owner who has shared its life and won its confidence and trust can be huge, and one of the sweetest things in life.  But it doesn't come instantly.  Compare it to your kid's first day of daycare or kindergarten.  You shouldn't feel bad if the kid runs eagerly to meet the other kids without a backward look at you.  If he hangs back and clings to you, that's not necessarily a bad thing, but it's not as promising as a youngster who is focused on its exciting new world rather than on you.

    Dogs vary also in their natural activity level.  Some are much more laid back than others.  But if your pup really sleeps most of the time, it wouldn't hurt to take her to a vet to see if there is any underlying health cause.

  16. I sure hope so — the researchers are working intensively on this from several different directions and are optimistic — but I’ve learned that you never know with science.  If so, it will have been well worth waiting.  But in any case,  we will be issuing another statement within a year, reporting where we are at that point, and reassessing the best ways to proceed in light of that.

  17. On 9/27/2019 at 11:40 PM, Liz P said:

    "The ABCA HEF does not endorse this marker test, nor do we encourage people to test at this time, before the causative mutation is found."  <--- this line right here

    Here's the full paragraph, from which you quote one sentence: 

     The ABCA HEF does not endorse this marker test, nor do we encourage people to test at this time, before the causative mutation is found. But at the same time, we are not telling people not to test. The test does have some significant benefits, especially for someone whose dogs have deafness somewhere in their pedigree and who must make a breeding decision in the immediate future or who is considering buying or beginning the training of a young dog with deafness in its pedigree. The presence of deafness in a pedigree greatly increases the chances that the marker set will be associated with a causative mutation. The decision whether to purchase the test at this stage is yours alone, but in making that decision here are some factors we think you should consider.  [Emphasis added]

    On 9/27/2019 at 11:40 PM, Liz P said:


    So what are you saying I should do in the case of my bitches, who are all carriers?  Ignore the test results and breed to any stud?  What would I tell those puppy buyers if their dogs go deaf?  That I chose to ignore the results of the best testing option we had at the time?

    I don't know, Liz.  Do you have to breed all of your bitches within the next year?  I'm not familiar with them, so I don't know how urgent the need is.  If you feel that you do, then yes, find a stud who tests Clear, while of course giving at least as much consideration to the dog's suitability as a cross with your bitches.

    On 9/27/2019 at 11:40 PM, Liz P said:


    My plan was to breed the carrier bitches, but only to dogs that tested clear.  According to the ABCA statement, those clear dogs have zero risk.  That is the safest choice for me right now to save a bloodline.  The problem I am having is that many stud owners already decided before the announcement that they would not bother testing.  Now more have said that they won't bother.  My options were just reduced even further.  You want to save genetics?  Encourage testing.

    ABCA and HEF have always encouraged utilization of tests for deleterious genetic mutations, as well as supporting the research aimed at producing those tests.  But we cannot encourage wholesale testing with this marker test -- it would be irresponsible.  The cause of genetic testing would not be advanced if we urged people to use a test that was later found to have given flawed results regarding their dogs.   

    I wish the EAOD research we've sponsored had succeeded in identifying the causal mutation, as it appeared for a time it had, but ultimately it has not yet done so.  We are trying to give full information about the test, and to strike a balance between the competing considerations that are implicated here.  Each person must make his/her own decision about testing, including the stud owners you refer to.

    Also, it's important to keep in mind that, while breeding carriers to clears is often a good strategy in the short run because it ensures that the offspring will not be affected, it will not work indefinitely in a case where the deleterious gene is carried by a large percentage of the population, because its effect is to increase the percentage of carriers in the population over time.    

  18. 1 hour ago, Liz P said:

    I am surprised by a statement that agrees that dogs found clear of the linked genes will not go deaf, which implies you could safely breed those dogs to the carriers and at risk dogs and never produce an affected puppy, and yet the ABCA basically just shot this test down by not supporting it. 

    When you say "shot this test down," it sounds as if you think that we somehow prevented it from being offered, or prevented people from using it.  That is certainly not not the case.  The test is still there and anyone can choose to use it.  Our statement is intended to make sure that people recognize the limitations of the test -- that they do not drift into assuming that the results mean more than they do.

    1 hour ago, Liz P said:

     With such a high carrier rate we can't afford to eliminate all these dogs from the gene pool, as your statement said.  Nor can we safely keep them in the gene pool without the test.  Every single one of my bitches tested as a carrier.  I had ONE dog come back clear.  I know others in the same boat.  How in the world can we safely proceed with a bloodline unless we utilize testing?  How in the world can we find safe stud dogs to put to our bitches unless people test?

    It seems to me that this is an example of someone putting more faith in the test than it merits.  You are assuming that the carrier results are definitive -- that they really mean the dog is a carrier of the EAOD causal mutation.  That's exactly why we felt obligated to set forth our reservations about the test.  In a test that directly tests for the causal mutation, a carrier result means that the dog is actually carrying the causal mutation.   Here in this marker test, the term "carrier" is really a misnomer.  It does NOT necessarily mean the dog is carrying the causal mutation, which is what we were trying to explain.  DO NOT LOSE SIGHT OF THAT FACT.  (For one explanation of why this is so, see the attached scenario, which is an internal working document the HEF used in the course of developing our statement.)

    There are some situations where one might feel a need to use the test in its present form.  We mention some of them in the statement.  Another instance where the current test would be useful is if you are buying a pup or about to start training a dog -- a "Carrier" result for that dog would give pretty good assurance that the dog would not lose its hearing early, because it has at least one Clear set of markers.  But for the many people who do not have to make those kinds of decisions immediately, waiting to see if a test for the mutation itself is forthcoming makes all kinds of sense.  

     

                              

       

     

    EAOD marker test - One Possible Explanation.docx

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