EOAD and ABCA Health Foundation Research
Posted 12 December 2016 - 07:20 PM
Just curious if there is an updated to the research the foundation is doing? Any news? Or did I miss it on the website?
Also, I'd like to ask...is there anyway the ABCA will walk back their comments on ProjectDog and their research and join them (collaborate) so we're not necessarily reinventing the wheel? Is none of their data valid?
I have no scientific education whatsoever! That's why I'm asking..
Posted 12 December 2016 - 09:19 PM
Posted 12 December 2016 - 09:22 PM
Posted 12 December 2016 - 09:47 PM
Posted 12 December 2016 - 11:24 PM
It was my understanding that the genetics in the Lohi research were from US dogs to begin with. No?
This is the paper I was reading. However, I cannot locate a date that the study began.
Posted 13 December 2016 - 05:28 AM
The testing to date has not identified the marker(s) that are associated with eaod (btw Plos is for publishing results fast with very little peer review). No one can predict when the marker for eaod will be identified. What the CEA discussion was for is to provide everyone with a sense of timing between when the marker is identified to when a test could be developed that is predictive for a dog developing eaod.
The linked article indicated that samples from Finnish dogs were used as controls. Most of the affected dogs in the linked article were North American. I do not believe those samples were made available to Lohi by Neff.
My biggest regret during these past years is how long we waited for Neff to return with the desire to do more studies on eaod (we waited because we thought he was the farthest along in the research). Early on he provided me with "his cell number"; however there were many months/years where he did not answer calls, the voice mail box was full, and emails went unanswered. He promised to share our samples with other researchers but never did so. They did not properly lable the samples from the epilepsy study making them unusable for futher studies. These are not the behavior of most researchers.
Posted 13 December 2016 - 08:08 AM
Can we be updated as to how many samples from the categories requested have been submitted? How many more are needed?
Is Dr Lohi starting over?
Posted 13 December 2016 - 11:03 AM
I trust the data in the article (you linked the correct article); some of the conclusions presented by Neff are still up for debate (even amongst the co-authors).
Dr Lohi is not starting over, the data in the article (and the collaboration with Neff for the article) provided him with a starting point for the research he continued while we were waiting for Neff to re-emerge interested in continuing his study on EAOD.
I do not have updated numbers on samples; but providing an update to our community on sample collection is a good idea that I will bring up with the other directors of the HEF.
Posted 13 December 2016 - 11:15 AM
Posted 13 December 2016 - 08:15 PM
Mark, could you please provide an address for where I can send a sample. I have a bitch who had normal hearing but produced an EOD affected pup. He has documented BAER tests starting at 6 weeks old and no ear infections, injuries, etc.
Posted 13 December 2016 - 09:57 PM
- Dogs affected with early adult onset deafness (EAOD) who went deaf between the ages of 2 and 8.
- Dogs with idiopathic epilepsy who are over the age of 8 with no loss of hearing.
- Dogs without hearing loss or epilepsy who are over the age of 8, from lines with no known incidence of epilepsy or hearing loss.
- Dogs unaffected by EAOD, who were bred to dogs that did become affected with EAOD, and who produced at least 8 pups from such mating(s) (in one or more litters), all of whom reached the age of 8 with no hearing loss.
She does not fit any of those criteria. She was bred to a male who had normal hearing last I heard (at 11 years old) and they produced and EOD affected dog.
Posted 14 December 2016 - 09:51 AM
Celt, Megan, and Dan
"When the chips are down, watch where you step."
"The happiest people don't necessarily have the best of everything. They just make the best of everything." - author unknown
Posted 15 December 2016 - 07:16 PM
Liz, I understood that your sample was from Freya, who is now deceased? If you haven't already followed the procedure Mark suggested (or even if you have), you can mail your sample (it's a swab, right?) to me. The last time we discussed this was in August, and I suggested that you wait until somewhat cooler weather, not wanting to run the increased risk of bacterial growth in that heat. The researchers want 3 swabs per dog, so please send 3 if you have them. Please include a copy of Freya's pedigree and a completed questionnaire/consent form (see attached). Please send in a padded (not plastic) envelope. I will record your sample in the database and forward to UMN. The same goes if the bitch you're asking about is not Freya, but one who is alive now.
Posted 25 October 2017 - 05:45 AM
Posted 25 October 2017 - 06:47 AM
What everyone wants to know is has a correlation been found between one gene and eaod? Not yet
When this correlation is found we still will not have a proven test for eaod. Unlike what another group indicated, finding a gene that is correlated to eaod does not prove that gene is predictive of a dog developing eaod. We won't have a test like the one for CEA.
Extensive testing of that gene will need to be performed to prove it is predictive of dogs developing eaod (like what was done for CEA). Since it takes years for dogs to develop eaod (unlike CEA) we will want an extensive data base of samples (that were not included in the gene identification work) and the hearing status of those dogs at 8years or older so we can take years off of the test validation study. We don't want to wait years for those dogs being used to validate a possible test to reach an age where the eaod status is known.
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