Jump to content


Photo

Request for Participation in Border Collie Study


  • Please log in to reply
21 replies to this topic

#1 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 14 September 2010 - 11:14 AM

Dr. Sue Taylor, Dr. Jim Mickelson. et. al. are studying what they have called Border Collie Collapse (similar in appearance to Exercise Induced Collapse). They are soliciting both affected an unaffected dogs for their ongoing research. If you are willing to participate please read the information below.

The ABCA is funding the clinical study phase of their research.



Border collie Collapse (BCC) Study
Dogs with Border collie collapse (BCC) may become abnormal after five to fifteen minutes of strenuous activity, particularly in warm weather. Affected dogs commonly develop a stiff, stilted gait with short strides and may scuff their feet during walking. They may seem dazed and confused or may simply lose their focus. Some dogs get very wobbly or appear "drunk" and a few dogs actually become unable to walk. Dogs recover completely with no residual lameness or muscle stiffness or discomfort.

How can you help?
We are currently collecting questionnaires and DNA (EDTA blood) samples and pedigrees from Border Collies suspected to have BCC.

Questionnaires
If your Border collie has had 2 or more episodes of exercise intolerance or collapse that may be BCC, please go to this website for the Canine and Equine Genetics Lab at the University of Minnesota:

http://www.cvm.umn.edu/vbs/faculty/Mickelson/lab/home.html

Click on Border Collie Collapse under Canine Research
To fill out the online questionnaire and submit it electronically right away select the BCC questionnaire option.

Blood Sample for DNA
Instructions for collecting and shipping the DNA sample (EDTA preserved blood), and forms to accompany the sample shipped to the laboratory in Minnesota are also available on the website above. When you send a DNA sample in from your dog to the University of Minnesota, realize that there will be no "test result" forthcoming. The DNA will be used to achieve our long term goal of identifying the genetic cause of BCC.

Video
If you have a video of your dog having an episode of collapse we would also like to have the opportunity to view that. Send it to us electronically (sue.taylor@usask.ca) or send a CD/DVD with the video to Dr. Taylor. (Dr. Sue Taylor, Dept of Small Animal Clinical Sciences, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N5B4)

Exercise Study
We are also still looking for a few severely affected dogs who would be willing to travel to Saskatoon, Saskatchewan Canada to participate in the exercise phase of our study. This will involve bringing or shipping your dog to Saskatoon, where we will perform thoracic radiographs, EKGs, cardiac echo, and clinical and blood tests before and after your dog participates in an exercise study. The next day, general anesthesia will be performed for diagnostic testing and muscle biopsy. Estimated time required in Saskatoon is 3 days. Funding is in place to help defray the cost of dog travel.

Ball chasing dogs can come individually for evaluation (stay for a Monday, Tuesday Wednesday).
Sheep herding dogs will be evaluated together on one day in May or June 2011 - time to be arranged.

Please contact Dr. Taylor if you are interested (sue.taylor@usask.ca).


Border collie Collapse (BCC) Study - NORMAL DOGS NEEDED
Dogs with Border collie collapse (BCC) may develop gait and mentation changes during or after strenuous exercise. In addition to describing and characterizing the syndrome of BCC we are trying to identify the heritability and genetic cause of this disorder. In order to find the genetic cause for BCC it is important that we have DNA from a large number of clearly unaffected (control) Border collies who have been worked at maximum capacity yet never exhibited any evidence of exercise intolerance.

How can you help?
If your dog is at least 3 years old (preferably 5 or older) and has engaged repeatedly in strenuous activity (especially herding) without ever showing any evidence of exercise intolerance, incoordination or collapse it would be very helpful if you would fill out a short questionnaire and have your veterinarian send us a blood sample from your dog. We need many more samples from normal control dogs who definitely do not have BCC.

Questionnaires
If you have a normal BCC and you are willing to participate in our study, please fill out the attached (see below) short questionnaire and ship a copy with the sample.

Blood Sample for DNA

Have your veterinarian collect 5-10cc of whole blood, place it in an EDTA (lavender top) tube and mix gently. The sample should be refrigerated until it is shipped.

The tube should be labeled with the dog's call name and owner last name and the words "NOT AFFECTED".

Whenever possible a copy of the questionnaire for this dog and a copy of their pedigree (with this dog highlighted) should be included in the package with the sample (place in a plastic bag so it does not get damp).

Have your vet pack the sample and the paperwork in a small box or insulated container with a cool pack. Ship to arrive in 2 to 5 days (overnight is not necessary) to:


University of Minnesota
c/o Katie Minor
1988 Fitch Ave
295 AS/VM
St. Paul, MN 55108
612-624-5322


The questionnaire is available upon request (send a PM to me).
Support the ABCA Health & Education Foundation by using Amazon Smile

#2 diane allen

diane allen

    Senior Member

  • Registered Users
  • 1,477 posts

Posted 14 September 2010 - 11:49 PM

It's kinda late this evening when I'm looking at this....but it looks like they are only soliciting dogs who can travel to Sask. to participate....is that correct for now?

diane

#3 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 15 September 2010 - 04:24 AM

For the affected dogs, that is correct. Sue Taylor needs to evaluate the affected dogs and she is in Sask.

Mark
Support the ABCA Health & Education Foundation by using Amazon Smile

#4 2 Devils

2 Devils

    5 Devils and counting

  • Registered Users
  • 2,393 posts

Posted 15 September 2010 - 07:41 AM

Mark - can I assume it would be ok to post this on other forums? I can post to the big flyball list or even smaller ones.
Kim
Warrenton, VA
Posted Image

#5 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 15 September 2010 - 09:41 AM

Kim,

For ease of providing the info, post the the link to the study's website: Border Collie Collapse

Mark
Support the ABCA Health & Education Foundation by using Amazon Smile

#6 2 Devils

2 Devils

    5 Devils and counting

  • Registered Users
  • 2,393 posts

Posted 15 September 2010 - 11:25 AM

Thanks Mark. I have sent to a large flyball list that reaches probably a couple thousand folks. Hopefully this will help get more border collies entered in the study.

I also gave permission to cross post so that should also help.
Kim
Warrenton, VA
Posted Image

#7 Ancarrow

Ancarrow

    Member

  • Registered Users
  • 62 posts
  • Gender:Female
  • Location:Monterey, VA
  • Interests:Dogs, sheep, horses, chickens, old milk cow & a token goat.

Posted 16 September 2010 - 08:28 AM

Oh my, just watched Denise Wall's video off the link, and it is exactly what my Joe does! We have gotten to where we just don't try to use him at all if the weather is even slightly warm. I must contact them on his behalf. Thanks for sharing this.

#8 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 07 October 2010 - 05:32 PM

It's kinda late this evening when I'm looking at this....but it looks like they are only soliciting dogs who can travel to Sask. to participate....is that correct for now?

diane



Hi Group!

I am the study coordinator at the University of Minnesota. We are interested in ALL affected dogs for the genetic study. You do not have to have your dog formally evaluated by Dr. Taylor in Saskatoon to participate in the genetic portion of the study. For the exercise testing, yes, you (or your dog) do need to travel to Saskatoon. Dr. Taylor does have funds available to help defray the cost of traveling expenses.

We can help you decide if your dog fits the profile of a BCC affected dog by evaluating our online questionnaire, and videos if available. To complete our questionnaire, please follow this link:

http://www.cvm.umn.edu/vbs/faculty/Mickelson/lab/EIC/bordercollieEIC/Survey/index.htm

Please let us know if you have any questions,

Katie Minor

University of Minnesota
Canine Genetics Lab

612-624-5322
minork@umn.edu

#9 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 20 January 2011 - 02:07 AM

Border Collie Collapse (BCC) Study Update

Hello Everyone,
I wanted to post a quick update on samples that we are interested in receiving for our BCC study.

To the University of Minnesota--

We are still very interested in receiving additional blood samples from affected or possibly affected dogs. If you are unsure if your dog fits our study criteria, please complete our online questionnaire.

We are also in need to controls for the genetic study. We are looking for blood samples from exercise tolerant, normal dogs that are at least 3 years of age. Ideally these dogs should have actively worked stock for a minimum of one season without obvious signs of collapse or exercise intolerance. Please consider having a blood sample drawn the next time you are in to your vetís office.

To the Western College of Veterinary Medicine--

We are still looking for dogs to travel to Saskatoon, Saskatchewan to participate in either sheep herding or ball chasing studies. All diagnostic testing will be provided free of charge, and travel funds are available. A group sheep herding time will be arranged for a to-be-determined time this Spring/Summer. Ball chasing dogs can be evaluated individually throughout the spring/summer when travel conditions improve.

For additional information on BCC, including-- a detailed description of collapse characteristics, videos, submission forms for normal and affected dogs, as well as information about the exercise study; please see our webpage:

http://www.cvm.umn.edu/vbs/faculty/Mickelson/lab/EIC/bordercollieEIC/home.html

Many thanks to those who have already participated in the exercise studies, and/or submitted blood samples.

Katie Minor

University of Minnesota
1988 Fitch Ave
295 AS/VM
St. Paul, MN 55108

phone: 612-624-5322
fax: 612-625-0204
minork@umn.edu

#10 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 18 February 2011 - 01:50 AM

We have now arranged a central shipping site for Australian Border Collie owners who would like to participate.

Submission forms and protocols are available on our webpage:

Border Collie Collapse

Katie Minor
University of Minnesota

#11 Northof49

Northof49

    Senior Member

  • Registered Users
  • 907 posts
  • Location:CANADA

Posted 18 February 2011 - 12:18 PM

q

#12 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 01 April 2011 - 02:14 AM

Update on BCC Exercise Study

Based upon information gathered from evaluating 10 Border Collie Collapse affected dogs at the University of Saskatchewan, we have removed the anesthesia, EMG and muscle biopsy components of evaluation. None of the BCC dogs tested have had abnormalities in their lab work or histology that would indicate that Border Collie Collapse is a muscular condition.

With the removal of these components, all testing can be preformed in a single day, and there will be no down time for recovery or suture care. If you are able to travel to Saskatoon, or to send your dog for testing, please contact Dr. Sue Taylor sue.taylor@usask.ca

All testing is provided free of charge, and up to $500 in travel funds is available.

Exercise Study

Many thanks,
Katie Minor, RN
minork@umn.edu

Border Collie Collapse Study

#13 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 26 July 2011 - 08:10 AM

The Border Collie Collapse study is still seeking participants both for sample submission and for field testing in Saskatchewan. If you are able, please participate in this ABCA funded study.

Mark Billadeau
ABCA Health & Genetics Committee Chair


Support the ABCA Health & Education Foundation by using Amazon Smile

#14 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 03 August 2011 - 02:39 PM

The Border Collie Collapse study is still seeking participants both for sample submission and for field testing in Saskatchewan. If you are able, please participate in this ABCA funded study.

Mark Billadeau
ABCA Health & Genetics Committee Chair



Dr. Sue Taylor is planning to wrap up the field testing at the end of September, and write her findings at that time. If you are able to travel to Saskatoon, please consider doing so this summer. If you have not submitted a sample for the genetic study yet, she can collect and ship the sample while you are in Saskatoon.

Travel funds are available to help offset your costs, or to fly the dog to Saskatoon for testing.

http://www.cvm.umn.edu/vbs/faculty/Mickelson/lab/EIC/bordercollieEIC/ExerciseStudy/index.htm

Katie Minor
University of Minnesota
Genetic Study Coordinator

minork@umn.edu

#15 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 07 February 2012 - 10:06 PM

We are hoping to begin our genome scan to look for the underlying genetic cause of Border Collie Collapse shortly.

We are still very interested in obtaining blood samples from as many affected dogs as possible.

We are also very interested in obtaining blood samples from older dogs (at least 5 years) from as many different lines as possible to use as study controls.

Please see our website for submission instructions or email our lab.

Katie Minor
University of Minnesota
BCC Project Coordinator
minork@umn.edu

Border Collie Collapse

#16 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 05 April 2012 - 04:20 PM

We are hoping to send samples for the BCC genome scan within the next month or so.

We would greatly appreciate additional samples from older unaffected border collies that have worked stock or competed in high activity level events, such as flyball or agility, without signs of exercise intolerance, collapse or disorientation. Ideally these dogs would be at least 5 years in age, and have competed for 2 years.

Please consider having a sample collected when you are next at your vets office. Samples can be sent via USPS for $5 or less. Submission forms are on our website.

Your participation is greatly appreciated.

Katie Minor

University of Minnesota

Border Collie Collapse

#17 airbear

airbear

    Talk to the paw

  • Registered Users
  • 2,543 posts
  • Location:Vancouver, BC

Posted 05 April 2012 - 04:40 PM

We would greatly appreciate additional samples from older unaffected border collies that have worked stock or competed in high activity level events, such as flyball or agility, without signs of exercise intolerance, collapse or disorientation.

Is there any value in blood samples from unaffected dogs who do not have a pedigree?

Kristi
Rex and Bar
Bear, Wick and Lou - forever in my heart
Our Photo Blog

The future belongs to those who believe in the beauty of their dreams - Eleanor Roosevelt


#18 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 05 April 2012 - 04:55 PM

Is there any value in blood samples from unaffected dogs who do not have a pedigree?



If you are confident they are a pure bred border collie, we will take dogs without a pedigree.

#19 Todd's Mom

Todd's Mom

    Member

  • Registered Users
  • 74 posts
  • Gender:Female

Posted 05 April 2012 - 11:58 PM

I have a retired 12 year old boy who played flyball, but he has competed in quite some time. He retired due to hip dysplasia though, not intolerance to activity. Do you want samples from dogs who currently compete in sports/stockwork only or those who have retired as well?

#20 Katie Minor, RN

Katie Minor, RN

    Junior Member

  • Registered Users
  • 21 posts

Posted 06 April 2012 - 03:20 PM

I have a retired 12 year old boy who played flyball, but he has competed in quite some time. He retired due to hip dysplasia though, not intolerance to activity. Do you want samples from dogs who currently compete in sports/stockwork only or those who have retired as well?



If they have successfully competed in the past without problems, we'll happily take them if they have since retired.


0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users

Copyright: All posts and images on this site are protected by copyright, and may not be reproduced or distributed in any way without permission. Banner photo courtesy of Denise Wall, ©2009 CDWall. For further information, contact info@bordercollie.org.