Jump to content


Photo

Border Collie Studies Sample Collection Website


  • Please log in to reply
26 replies to this topic

#21 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 09 January 2014 - 08:37 AM

Julie,

 

Based upon the science I personally see no reason to excude from breeding a sire or a dam that produced epilepsy; just don't repeat the cross that produced epilepsy.

 

The ABCA recomendations on breeding are: Do not breed affected dogs. If two unaffected dogs produce an affected puppy, do not repeat that cross.


Support the ABCA Health & Education Foundation by using Amazon Smile

#22 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 09 January 2014 - 08:37 AM

Elizabeth,

Dr Neff has been working on developing the necessary web based data collection and lab data management system before he can offer this risk test on EOD. I have not heard from him letting me know his system is ready for use. When it is ready there will be announcements.

 

Mark


Support the ABCA Health & Education Foundation by using Amazon Smile

#23 Liz P

Liz P

    optimistic realist

  • Registered Users
  • 5,234 posts
  • Gender:Female
  • Location:somewhere inside my brain

Posted 09 January 2014 - 08:55 AM

It would be really nice if he could e-mail initial results on dogs that were used in the study to their owners.



#24 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 09 January 2014 - 09:08 AM

In a Genome Wide Association Study (GWAS) the dogs tested had been clinically assigned as affected or normal, from that assignment he then looked at the genetics to find where in the genome the affected dogs were different from the normal dogs.  Dogs with unknown status cannot be used for a GWAS.  How would these data be of use to owners?  The owners already know the status of their dogs.


Support the ABCA Health & Education Foundation by using Amazon Smile

#25 Liz P

Liz P

    optimistic realist

  • Registered Users
  • 5,234 posts
  • Gender:Female
  • Location:somewhere inside my brain

Posted 09 January 2014 - 10:06 AM

Would be nice to know if our related dogs were suspected carriers or likely clear.



#26 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 09 January 2014 - 10:12 AM

Not all samples submitted were tested; only those dogs that met the study requirements were tested.  It was cost prohibitive to test every sample submitted.  Including too many closely related dogs would have skewed the data away from a "genome wide" study towards a familial study.  Only affected dogs and normal dogs were tested; those of undetermined status were not tested.

 

Offspring of an affected dog will either be a carrier or affected.

 

The risk test Dr Neff is developing may provide the answers you seek.


Support the ABCA Health & Education Foundation by using Amazon Smile

#27 Mark Billadeau

Mark Billadeau

    Bill Nye Wannabe

  • Registered Users
  • 3,159 posts
  • Gender:Male
  • Location:Middletown, MD
  • Interests:science, working dogs, sheep

Posted 10 January 2014 - 08:29 AM

The results of the genome wide association study cannot be used to identify dogs that are affected or are carriers of EOD; it is a correlation study not one that establishes cause and effect.  The results from this study can only be used to guide the next step (of several steps) towards identifying the gene(s) that do cause EOD.


Support the ABCA Health & Education Foundation by using Amazon Smile


1 user(s) are reading this topic

0 members, 1 guests, 0 anonymous users

Copyright: All posts and images on this site are protected by copyright, and may not be reproduced or distributed in any way without permission. Banner photo courtesy of Denise Wall, 2009 CDWall. For further information, contact info@bordercollie.org.