My old dog was on Advocate (flea/worm preventative) in her early years which contains moxidectin and imidacloprid. I switched to other products when someone said it was a risk as 30/40% of collies carry a gene which makes them sensitive to ivermectin, moxidectin and other drugs. I must admit I was never comfortable with dosing with a systemic insecticide anyway. Ben the new dog was given Advocate while in the Rescue and I am trying to decide whether to continue with it. Vets here seem to push Advocate - border collie or not. Just wondered whether anyone had their dog tested or avoids certain drugs 'just in case'.
Border collie sensitivity to ivermectin and other drugs
Posted 19 March 2017 - 04:32 PM
Here is a link to a FAQ for the mdr1 gene:
I wouldn't worry about a border collie, but Lassie-type collies and Australian shepherds have quite a high incidence.
"Folks will know how large your soul is by the way you treat a dog." Charles F. Duran
Posted 19 March 2017 - 05:09 PM
Not far from you pineapple. I wouldn't worry over much either, just don't overdose.
I think the risk of the MDR1 gene in BCs is less than 5%.
Posted 19 March 2017 - 05:57 PM
You can read more about the MDR1 gene mutation on Washington State University website. (Just google Washington State University VCPL MDR 1 test.) Border Collies are less than 5% affected. I had both of mine tested anyway, just for curiosities sake and they were both negative/negative.
Posted 19 March 2017 - 06:44 PM
I have to say my old girl never had a reaction - though she did seem sensitive to drugs generally. We used to start at the low end of a dose and work up.
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